QUESTION: As a paraplegic, I have wondered what the effects of microgravity might be on the natural effort by the body to repair the CNS, especially the Spinal Cord. Have any research procedures been planned with that in mind (I believe that the Embryonic growth of CNS fibers may be effected by micro-gravity, in the sub-cellular, i.e genetic, condition) Also, has NASA considered the position of the physically disabled in space. Paraplegics suffer, on a day to day basis, the effects of lousy circulation; a weakened skeletal structure and disturbance of the immune system (amongst others) and learn how to survive these effects with ease. If NASA could put a paraplegic in an environment absent from gravity for an extended period of time, and observe the physical changes within the paralysed body - something very rewarding may be learned. Any interest in putting somebody like myself into such an environment? ANSWER from Louis Ostrach on November 19, l997 In fact, the Adult Neuronal Plasticity Team is studying how the central nervous system responds to the novel environment of microgravity by altering the connections and functions of various groups of nerve cells. They will also study the re-adaptation of the brain when the animals return to the one-g of Earth upon recovery of the shuttle experiment. Similarly, the cricket experiment, Dr. Eberhard Horn of Germany, is studying the regeneration of specific sensory nerves in micro-gravity and in 1-g control specimens. NASA is indeed very interested in the basic science of nerve regeneration and the potential for applied benefits. Your suggestion about flying a paraplegic astronaut is intriguing and poses many interesting questions and possibilities for research. I'm not aware, however, of any definite plans to follow through on this suggestion.