QUESTION: I have found that the heart and the musculoskeletal system seem to be the areas most effected by zero gravity. Are there others and how do they help or hinder an astrnauts performance? ANSWER from Bonnie P. Dalton on April 2, 1998: Your information is correct concerning the vascular and musculoskeletal system. You are probably aware that there is a program within NASA called countermeasures which is the conduct of varioius studies to determine what kind of activities should be conducted to counteract the effect of microgravity on the body while in space. Because of the effects of microgravity on the human system, the crew has a regular regime of exercise while up there and there has been a constant plea with the crew to continue on a prescribed exercise regime when they return. Unfortunately, it is up to the crew persons to choose to follow these requests or to disregard them. Also the effects are more severe for the long term missions, e.g., MIR space station where the crew has been up for 45-90 days. It often takes 6 months to 3 years to recover and gain full muscular strength from such missions. How rapidly this occurs, is dependent on the return exercise and the individual. We know that bone cells are laid down differently in rats flown in space (0g) then they are on earth (1g). Of course the metabolism of a rat is much more rapid than that of a human. As an example, the maturation of a neonate (baby rat) from conception to birth is 20 days versus 9 months for a human. But we can deduct similar bone happenings in human. We don't have enough statistical data on humans on long term missions, due to the fact we've not had that many people up there and we've not seen long term effects, e.g., does someone in space have greater muscular problems and bone problems in older age. In short, much still needs to be learned. Some early information has been obtained on rats on the effects on the hair cells in the air and thus the effects on balance. Hopefully the Neurolab mission will given increased information and also other info concerning the brain specifically, e.g., memory retention, nerve firings, adaptation and nerve firings involved in micro-g. In terms of performance of the crew in space. Remember, they are performing in a weightless environment so they don't have to work against a resistive force. In terms of performance and space motion syndorome (space sickness), processes have been developed and Russian and some US crews trained to monitor their pulse, temperature, and heart rate and then perform activities to counteract the increased elevation of these elements and thus avoid motion sickness.