Who I am and What I do:
I am currently Assistant Professor in the Departments of Biomedical Engineering, Microbiology, and Physics at McGill University, Canada. My work focuses on development of novel labeling techniques for environmental samples as well as diagnostic medical imaging. I am also an Associate Member of The Jackson Laboratory in Bar Harbor, Maine and of the Department of Physics at the University of Maine, Orono, where I spend 20% of my time. Prior to that, I was a scientist at the Jet Propulsion Laboratory and visiting professor at the California Institute of Technology, focusing on instrument development for in situ life detection.

Areas of Expertise:
I have extensive experience in fluorescent labeling of microorganisms and development of instrumentation and techniques for in situ life detection. I have published these results in Astrobiology, Applied and Environmental Microbiology, and several other journals. I have been the Principal Investigator on one NASA ASTID and one NASA ASTEP for the development of wet-chemistry instruments for Mars missions, and am currently funded by the Canadian Space Agency for creation of several types of microscope for field and space use.

Selected Publications:

1. “Power and wavelength dependence of photoenhancement in (CdSe)ZnS-dopamine in aqueous solution and live cells,” S. Clarke, S. Koshy, J. Zhang, N. Cohen, J. Nadeau, Z. Phys. Chem, in press
2. “Fluorescence intensity and intermittency as tools for tracking bioconjugate processing in living cells,” R. Khatchadourian, S. Clarke, A. Bachir, P. Wiseman, and J. Nadeau, J Biomed Biotech, in press (Special issue on Biomedical Applications of Colloidal Nanocrystals; M. Osinski, guest editor; scheduled for March 2008)
3. * “Tracking of quantum dot surface properties and spectral changes with o-phthaldialdehyde,” S. Clarke, C. A. Hollmann, and J. L. Nadeau, Bioconjugate Chemistry Mar-Apr;19(2):562-8. Epub 2008 Jan 18.
4. “Fluorescence microscopy as a tool for in situ life detection,” J. L. Nadeau, N. Perreault, T. D. Neiderberger, L. G. Whyte, H. J. Sun, and R. Leon, Astrobiology, in press
5. *“Reconstitution of ion channels in agarose-supported silicon orifices,” Joshua A. Maurer, Victor E. White, Dennis A. Dougherty, and Jay L. Nadeau, Biosensors and Bioelectronics, 15;22(11):2577-84 (2007)
6. * “Photophysics of dopamine-modified quantum dots and effects on biological systems,” Samuel J. Clarke, C. Annette Hollmann,Zhijun Zhang, Diana Suffern, Stephen E. Bradforth, Nada M. Dimitrijevic, William G. Minarik and Jay L. Nadeau, Nature Materials5(5):409-17 (2006)
7. * “Photo-physical properties of biologically compatible CdSe quantum dot structures,” Kloepfer JA, Bradforth S, Nadeau JL, Journal of Physical Chemistry B 109: 9996-10003 (2005)
8. * “Uptake of CdSe and CdSe/ZnS quantum dots into bacteria via purine dependent mechanisms,” Kloepfer JA, Mielke RE, Nadeau JL, Applied and Environmental Microbiology 71(5):2548-57 (2005)
9. “Electron irradiation effects on nanocrystal quantum dots used in bio-sensing Applications,” Leon R, Nadeau J, Evans K, Paskova T, Monemar B, IEEE Transactions on Nuclear Science 51(6) : 3186–3192 (December 2004)
10. * “FRET between CdSe quantum dots in lipid vesicles and water- and lipid-soluble dyes,” Kloepfer JA, Cohen N, Nadeau JL, Journal of Physical Chemistry B 108 (44): 17042-17049 (November 2004)
11. *“Quantum dots as species- and metabolism-specific microbiological labels,” Kloepfer JA, Wong M, Nealson KH, Stucky G, Nadeau JL, Applied and Environmental Microbiology 69(7):4205-1 (2003)